Search Research Equipment & Facilities

Mass directed auto purification system (preparative LC-MS)


The Waters Auto Purification HPLC/MS system (preparative LC-MS) provides users with the flexibility of using automated high-throughput runs for selective mass-directed fractionation. The configuration enables easy scale-up from:

  • analytical chromatography (micrograms)
  • semi-preparative chromatography (milligrams)
  • preparative chromatography (gram quantities)

In addition, a collection of columns (variety of sizes and chemistries) is available. The machine automates the collection of fractions detected by MS and or UV-VIS, tracks samples and fractions, and then presents the data in an easy-to-view format. The software can trigger collection using a variety of detector signals including:

  • PDA (UV/Visible)
  • Evaporative Light Scattering (ELSD)
  • MS
  • analog detectors


This system can be used for fast and mass directed purification of natural products extracts and new molecular entities important to food, pharmaceutical, agrichemical and other industries:

  • Primary metabolites
  • Secondary metabolites: phytonutrients and a broad range of other secondary metabolites 
  • Oligosaccharides
  • (Bio-active) peptides

Complementary Techniques

  • Grace Reveleris Flash system (designed to collect fractions of crude mixtures, using evaporative light scattering (ELSD) and UV detection)
  • MALDI-TOF MS (for further analysis of the isolated fractions)

Contact Mark Sanders
Contact Henk Schols




Agrotechnology & Food Sciences Group


Food Chemistry

Last edited by Oscar de Vos on 2020-10-08